ABSTRACT
Objective: Oral blood blister, also known as angina bullosa hemorrhagica (ABH), is a rare lesion involving the oral cavity and agitates patients due to its dreadful appearance. This review aims to summarize oral blood blister cases in the literature. Methods: This study is based on the PRISMA guideline. An online search was conducted in PubMed/MEDLINE and Scopus databases without any restriction, and 45 articles were included. Results: Oral blood blister was slightly more prevalent in women, with a ratio of 1.09. The patients' average age was 59.93, and more than half of them were in their lives fourth to sixth decades. Half of the lesions were located on the palate, whereas the tongue, buccal mucosa, lips, the floor of the mouth, and uvula were the other common sites, respectively. Almost one-third of the cases were asymptomatic;however, pain, bleeding, and burning sensation were common symptoms in others. Eating trauma was the most relevant causative factor of this entity (57 %), yet no admissible cause was mentioned in 25 % of the cases. Hypertension, diabetes mellitus, and endocrine disease were among the most frequently reported underlying disorders. COVID-19 has been reported in a confined number of cases. In 60 % of cases, no therapeutic intervention was mentioned, while using mouthwash (6.2 %) and topical analgesics (5.1 %) as means of medicament were also mentioned in the literature. Conclusion: Oral blood blister is more common in middle-aged and elderly patients and is slightly more frequent in women. Physical trauma is the major cause of this lesion. © 2023 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI